3D Bioplotter Research Papers

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Displaying all papers by D. Koper (1 results)

The Co-Incorporation of Zn/Cu or Zn/Co Ions Improves the Bone Regeneration Potential of PEOT/PBT–βTCP Composite 3D-Printed Scaffolds

Advanced NanoBiomed Research 2025 Volume 5, Issue 3, Article 2400139

Authors:M. Nikody J. Li D. Koper E. R. Balmayor R. Habibovic L. Moroni

Treatment of critical-sized bone defects remains challenging despite bone’s regenerative capacity. Herein, a combination of a biodegradable polymer possessing bone-bonding properties with bioactive β-tricalcium phosphate (βTCP) particles coated with osteogenic (Zinc) and angiogenic (copper or cobalt) ions has been proposed. βTCP was coated with zinc and copper (Zn/Cu) or zinc and cobalt (Zn/Co) using 15 mM (low) or 45 mM (high) metallic ion solutions. Composites were obtained by a combination of the βTCP with poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT) copolymer in a 50:50 ratio. Composites were additively manufactured into 3D porous scaffolds and their osteogenic and angiogenic properties evaluated using a direct…

Keywords:Tricalcium Phosphate Zinc Cobalt PEOT/PBT Mesenchymal stem cells (MSCs) HUVEC Bone Regeneration