3D Bioplotter Research Papers

Polycaprolactone (PCL), either in its pure grade or as a polymeric matrix for bio-composites, plays a key role in the biomedical and bioengineering industries. It is also considered a multifunctional and versatile polymer for bioprinting and bioplotting purposes, especially in tissue engineering. Herein, an undiscovered yet valuable aspect of PCL extrusion-based bioprinting, such as the predictability of Critical Quality Indicators (CQIs), is investigated in depth. With the aid of the robust L25 orthogonal matrix design, the six most generic and device-independent control factors proved their impact on quality metrics such as global porosity, dimensional conformity, and surface roughness, determined with…

Bioplotting has high potential for the 3D printing of scaffolds and cellular structures. Medical-grade poly(ε-caprolactone) (PCL) is characterized by low 3D printing temperatures and strengths compared to those of common polymers. Thus far, research on PCL in bioplotting has mainly focused on improving its performance through the development of composites. In this study, the quantitative impact of six common 3D plotting settings on the engineering strength of PCL parts was evaluated. Three modeling approaches were implemented: linear regression modeling (LRM), reduced quadratic regression modeling, and quadratic regression modeling. The LRM results were not as accurate as those obtained using the…