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3D Bioplotter Research Papers
Displaying all papers by T. Eickner (1 results)
Development of a drug delivering round window niche implant for cochlear pharmacotherapy
Drug Delivery
2024
Volume 31, Issue 1, Article 2392755
Background There exists an unfulfilled requirement for effective cochlear pharmacotherapy. Controlled local drug delivery could lead to effective bioavailability. The round window niche (RWN), a cavity in the middle ear, is connected to the cochlea via a membrane through which drug can diffuse. We are developing individualized drug-eluting RWN implants (RNIs). To test their effectiveness in guinea pigs, a commonly used model in cochlear pharmacology studies, it is first necessary to develop guinea pig RNIs (GP-RNI). Methods Since guinea pigs do not have a RWN such as it is present in humans and to reduce the variables in in vivo…