3D Bioplotter Research Papers
Displaying all papers by Y. Nie (1 results)
A 3D-printed PCL/PEI/DNA bioactive scaffold for chemotherapy drug capture in vivo
International Journal of Biological Macromolecules
2023
Volume 236, Article 123942
Systemic chemotherapy after surgery is necessary to control tumor recurrence, but the severe side effects caused by chemotherapeutic drugs pose a great threat to patients’ health. In this study, we originally develop a porous scaffold used for chemotherapy drug capture by using 3D printing technology. The scaffold is mainly composed of poly (ε-caprolactone) (PCL) and polyetherimide (PEI) with a mass ratio of 5/1. Subsequently, the printed scaffold is modified with DNA through the strong electrostatic integration between DNA and PEI to endow the scaffold with the specific absorption to doxorubicin (DOX, a widely used chemotherapy drug). The results show that…