3D Bioplotter Research Papers

Conventional ocular formulations of moxifloxacin (MOX) are inefficient at maintaining an effective concentration of the drug in the tear film due to anatomical and physiological barriers of the ocular globe. In this project, 3D-printed inserts containing liposomal moxifloxacin (SL: MOX) were developed to increase ocular contact time and penetration of drugs. Moxifloxacin was encapsulated into lecithin liposomes (SL: MOX) with an efficiency of 80 %; the size was 150 nm as measured by Dynamic Light Scattering (DLS). An ex vivo study evaluated the antibacterial susceptibility of the MOX, SL: MOX, and a marketed product. Ocular inserts were then formulated and…