3D Bioplotter Research Papers

A challenge in tissue engineering and the pharmaceutical sector is the development of controlled local release of drugs that raise issues when systemic administration is applied. Strontium is an example of an effective anti-osteoporotic agent, used in treating osteoporosis due to both anti-resorptive and anabolic mechanisms of action. Designing bone scaffolds with a higher capability of promoting bone regeneration is a topical research subject. In this study, we developed composite multi-layer three-dimensional (3D) scaffolds for bone tissue engineering based on nano-hydroxyapatite (HA), Sr-containing nano-hydroxyapatite (SrHA), and poly-ε-caprolactone (PCL) through the material extrusion fabrication technique. Previously obtained HA and SrHA with…

Porous bioceramic scaffolds were obtained by the 3D printing technique starting from a mixture of hydroxypropyl methyl cellulose and a powder obtained by sol-gel method which contains merwinite, monticellite, pseudowolastonie and periclase.The scaffolds were thermally treated at 1370 °C for 3 h and the main mineralogical compound assessed by XRD was akermanite. The obtained scaffolds have adequate mechanical and biological properties thus a great potential for applications in hard tissue engineering. The positive results obtained for this type of scaffolds are due to the precision of 3D printing technique, i.e. ability to control shape and size of both scaffolds and…

In bone tissue engineering, 3D printing technology represents a promising means to obtain complex architectures with the possibility to control precisely the pore size.Diopside (CaMgSi2O6) is a biomaterial which has the ability to induce in vitro apatite formation and in vivo growth and differentiation of the osteoblast. CaMgSi2O6 is a biocompatible material that possesses good bending strength and fracture toughness, bioactivity and slow degradation rate. Due to its outstanding properties diopside has tremendous potential in medical applications.