3D Bioplotter Research Papers

Pancreatic ductal adenocarcinoma is one of the cancers with the least favorable survival prognosis worldwide. It is characterized by a high desmoplastic stroma rich in collagen I, which regulates pancreatic cancer cells’ behavior. There is a critical need to develop desmoplastic 3D models for preclinical testing. In this study, bioinks that imitate the biochemical characteristics of pancreatic ductal adenocarcinoma were developed to observe the influence that the desmoplastic extracellular matrix has on cancer cells. The bioinks were made of gelatin methacrylamide, alginate, and different concentrations of collagen I. Cancer cells were able to proliferate in all bioinks, presenting high paclitaxel…

Breast cancer 3D in vitro systems that replicate key tumor characteristics could assist drug discovery by providing more clinically translational models. Breast tumors are formed by hierarchically organized cancer and stromal cells and the extracellular matrix, all of which contribute to the disease progression and treatment response. 3D-bioprinting has enabled the creation of anatomically relevant constructs that better recapitulate the tumor architecture. The extracellular matrix’s role in the tumor outcome has motivated the development of biomimetic bioinks. Among them, bioinks based on decellularized mammary glands can mimic many native biological cues. This work aims to develop a bioprinted 3D in…