3D Bioplotter Research Papers

10 Latest Papers Search by Year Search by Author Search by Keyword

Displaying all papers by A. Krasnoslobodtsev (1 results)

3D Bioprinting of Breast Cancer Models for Drug Resistance Study

ACS Biomaterials Science & Engineering 2018 Volume 4, Issue 12, Pages 4401-4411

Authors:Y. Wang W. Shi M. Kuss S. Mirza D. Qi A. Krasnoslobodtsev J. Zeng H. Band V. Band B. Duan

Adipose-derived mesenchymal stem/stromal cells (ADMSC) are one of the major stromal cells in the breast cancer microenvironment that promote cancer progression. Previous studies on the effects of ADMSC on breast cancer metastasis and drug resistance, using two-dimensional (2D) cultures, remained inconclusive. In the present study, we compared cocultured ADMSC and human epidermal receptor 2 positive breast primary breast cancer cells (21PT) in 2D and three-dimensional (3D) cultures and then examined their response to doxorubicin (DOX). We examined 3D bioprinted constructs with breast cancer cells in the middle and ADMSC in the edge region, which were made by using dual hydrogel-based…

Keywords:Methacrylated Hyaluronic Acid Gelatin Methacrylate Mesenchymal stem cells (MSCs) Breast Tumor Cells Irgacure 2959 Cell Printing in-vitro Cell Co-Cultivation Tumor research