3D Bioplotter Research Papers

Peripheral neural interfaces facilitate bidirectional communication between the nervous system and external devices, enabling precise control for prosthetic limbs, sensory feedback systems, and therapeutic interventions in the field of Bioelectronic Medicine. Intraneural interfaces hold great promise since they ensure high selectivity in communicating only with the desired nerve fascicles. Despite significant advancements, challenges such as chronic immune response, signal degradation over time, and lack of long-term biocompatibility remain critical considerations in the development of such devices. Here we report on the development and benchtop characterization of a novel design of an intraneural interface based on carbon fiber bundles. Carbon fibers…

The fabrication of neural interfaces (NIs) typically relies nowadays on the implementation of complex, expensive, and time-consuming photolithographic processes. Metals and polymers are the materials currently used to fabricate NIs. Conductive polymers could be an alternative to metals to enhance the biocompatibility of the devices. Additive manufacturing techniques provide an easier and low-cost approach to process and finely tuning the geometrical and morphological features of polymers. Here, we propose a 3D printing strategy for the fabrication of completely polymeric neural interfaces, based on extrusion printing. The materials have been chosen to enhance the biocompatibility of the devices. PDMS has been…

Nerve conduits may represent a valuable alternative to autograft for the regeneration of long-gap damages. However, no NCs have currently reached market approval for the regeneration of limiting gap lesions, which still represents the very bottleneck of this technology. In recent years, a strong effort has been made to envision an engineered graft to tackle this issue. In our recent work, we presented a novel design of porous/3D-printed chitosan/poly-ε-caprolactone conduits, coupling freeze drying and additive manufacturing technologies to yield conduits with good structural properties. In this work, we studied genipin crosslinking as strategy to improve the physiochemical properties of our…