3D Bioplotter Research Papers

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Displaying all papers by G. Rubí-Sans (1 results)

3D Bioprinting of Biomimetic Alginate/Gelatin/Chondroitin Sulfate Hydrogel Nanocomposites for Intrinsically Chondrogenic Differentiation of Human Mesenchymal Stem Cells

Biomacromolecules 2024 Volume 25, Issue 6, Pages 3312–3324

Authors:F. Olate-Moya G. Rubí-Sans E. Engel M. A. Mateos-Timoneda H. Palza

3D-printed hydrogel scaffolds biomimicking the extracellular matrix (ECM) are key in cartilage tissue engineering as they can enhance the chondrogenic differentiation of mesenchymal stem cells (MSCs) through the presence of active nanoparticles such as graphene oxide (GO). Here, biomimetic hydrogels were developed by cross-linking alginate, gelatin, and chondroitin sulfate biopolymers in the presence of GO as a bioactive filler, with excellent processability for developing bioactive 3D printed scaffolds and for the bioprinting process. A novel bioink based on our hydrogel with embedded human MSCs presented a cell survival rate near 100% after the 3D bioprinting process. The effects of processing…

Keywords:Alginate Methacrylate Gelatin Methacrylate Chondroitin Sulfate Methacrylate Graphene Oxide 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone Adipose Derived Stem Cells (ADSC) Cell Printing in-vitro Cartilage Regeneration