3D Bioplotter Research Papers

Displaying all papers by J. Bourke (1 results)

Defined, Simplified, Scalable, and Clinically Compatible Hydrogel-Based Production of Human Brain Organoids

Organoids 2023 Volume 2, Issue 1, Pages 20-36

Human brain organoids present a new paradigm for modeling human brain organogenesis, providing unprecedented insight to the molecular and cellular processes of brain development and maturation. Other potential applications include in vitro models of disease and tissue trauma, as well as three-dimensional (3D) clinically relevant tissues for pharmaceuticals development and cell or tissue replacement. A key requirement for this emerging technology in both research and medicine is the simple, scalable, and reproducible generation of organoids using reliable, economical, and high-throughput culture platforms. Here we describe such a platform using a defined, clinically compliant, and readily available hydrogel generated from gelatin…