3D Bioplotter Research Papers

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Displaying all papers by J. C. Doadrio (1 results)

ZnO-mesoporous glass scaffolds loaded with osteostatin and mesenchymal cells improve bone healing in a rabbit bone defect

Journal of Materials Science: Materials in Medicine 2020 Volume 31, Article 100

Authors:D. Lozano J. Gil-Albarova C. Heras S. Sánchez-Salcedo V. E. Gómez-Palacio A. Gómez-Blasco J. C. Doadrio M. Vallet-Regí A. J. Salinas

The use of 3D scaffolds based on mesoporous bioactive glasses (MBG) enhanced with therapeutic ions, biomolecules and cells is emerging as a strategy to improve bone healing. In this paper, the osteogenic capability of ZnO-enriched MBG scaffolds loaded or not with osteostatin (OST) and human mesenchymal stem cells (MSC) was evaluated after implantation in New Zealand rabbits. Cylindrical meso-macroporous scaffolds with composition (mol %) 82.2SiO2–10.3CaO–3.3P2O5–4.2ZnO (4ZN) were obtained by rapid prototyping and then, coated with gelatin for easy handling and potentiating the release of inorganic ions and OST. Bone defects (7.5 mm diameter, 12 mm depth) were drilled in the distal femoral…

Keywords:Mesoporous Bioactive Glass PCL Zinc Oxide Coating (Gelatin) Coating (Osteostatin) Mesenchymal stem cells (MSCs) in-vivo (rabbit) Drug Release Bone Regeneration