3D Bioplotter Research Papers

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Displaying all papers by J. Hunter (1 results)

In vivo evaluation of bioprinted cardiac patches composed of cardiac-specific extracellular matrix and progenitor cells in a model of pediatric heart failure

Biomaterials Science 2022 Volume 10, Pages 444-456

Authors:D. Bejleri M. J. Robeson M. E. Brown J. Hunter J. T. Maxwell B. W. Streeter O. Brazhkina H-J. Park K. L. Christman M. E. Davis

Pediatric patients with congenital heart defects (CHD) often present with heart failure from increased load on the right ventricle (RV) due to both surgical methods to treat CHD and the disease itself. Patients with RV failure often require transplantation, which is limited due to lack of donor availability and rejection. Previous studies investigating the development and in vitro assessment of a bioprinted cardiac patch composed of cardiac extracellular matrix (cECM) and human c-kit + progenitor cells (hCPCs) showed that the construct has promise in treating cardiac dysfunction. The current study investigates in vivo cardiac outcomes of patch implantation in a…

Keywords:Gelatin Methacrylate Eosin Y 1-vinyl-2-pyrrolidone Triethanolamine ECM Cardiac Progenitor Cells (CPC) Cell Printing in-vivo (rat) Cardiac Patch Soft Tissue Regeneration