3D Bioplotter Research Papers

Blood vessels play an important role in bone growth and fracture healing by providing nutrients and oxygen. Although great progress has been made in bone graft materials with good biological and physicochemical properties, vascularization of these materials remains an urgent challenge for bone regeneration. Herein, we report a novel 3D-printed mesoporous bioactive glass (MBG) scaffold (ICA/TMP@MBG) incorporating two unique extracts from Chinese medicine, namely tetramethylpyrazine (TMP) and icariin (ICA), for enhanced vascularization and bone repair. In vitro results showed that ICA/TMP@MBG could significantly upregulate VEGF secretion, thereby facilitating the formation of angiogenesis tubes in human umbilical vein endothelial cells (HUVECs).…