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3D Bioplotter Research Papers
Displaying all papers by M. B. Onal (1 results)
An in vivo study on the effect of scaffold geometry and growth factor release on the healing of bone defects
Journal of Tissue Engineering and Regenerative Medicine
2013
Volume 7, Issue 9, Pages 687–696
The hypothesis of this study was that the extent of bone regeneration could be enhanced by using scaffolds with appropriate geometry, and that such an effect could be further increased by mimicking the natural timing of appearance of bone morphogenetic proteins BMP-2 and BMP-7 after fracture. Bioplotted poly(ε-caprolactone) (PCL) disks with four different fibre organizations were used to study the effect of 3D scaffold architecture on the healing of bone defects in a rat pelvis model. Moreover, one PCL construct was further modified by introducing a nanoparticulate sequential BMP-2/BMP-7 delivery system into this scaffold. Scaffolds and functionalized construct along with…