3D Bioplotter Research Papers

Introduction: For the treatment of sudden sensorineural hearing loss (SSNHL), dexamethasone (DEX) delivery via silicone implants, customized to individual patient anatomy through 3D printing, may be used. To ensure safety, the sterility of these implants must be verified. Autoclaving was employed as a potential sterilization method, and the biocompatibility and bio-efficacy of 3D-printed, DEX-loaded implants, using three different medical-grade silicones, were assessed post-autoclaving.   Methods: UV-Silicone 60A MG (Momentive, Niskayuna, USA), Nusil Med-4960 (Avantor, Radnor, USA), and Amsil Silbione 24503-50 A (Elkem, Oslo, Norway) loaded with 0, 1, 10, or 20 (w/w) % DEX (caelo, Hilden, Germany) were 3D printed…

The regular way to determine the in vitro release rates of drugs from implantable drug delivery systems consists of the complete immersion of the implant into a medium. The medium surrounds the implant, and the diffusion of the drugs occurs across the whole implant surface directly into the medium. This method does not accurately model the release rates if the real diffusion only happens across only one part of the surface of the implant, through a membrane, and into a small volume of medium. It also does not address the anatomical shape of the studied structure. One example for this…