3D Bioplotter Research Papers

Within this work we applied the principles of biomimicry to develop printable and injectable gealtine-based bio-hybrid inks to target the regeneration of three different tissues: chondral tissue, bone tissue and neural tissue. Starting by the same natural biopolymer, gelatine, derived by hydrolysis of collagen, the main human body extra-cellular matrix (ECM) constituent, we exploited different process technologies, functionalization, and crosslinking techniques to develop devices suitable for the targeted tissues engineering. More specifically, we performed a process comparison among two process technology, three-dimensional printing, and mould casting, for the realization of three-dimensional scaffolds for chondral regeneration. We developed nano-hydroxyapatites (nHAs) functionalized…

Bioprinting of nanohydroxyapatite (nHA)-based bioinks has attracted considerable interest in bone tissue engineering. However, the role and relevance of the physicochemical properties of nHA incorporated in a bioink, particularly in terms of its printability and the biological behavior of bioprinted cells, remain largely unexplored. In this study, two bioinspired nHAs with different chemical compositions, crystallinity, and morphologies were synthesized and characterized: a more crystalline, needle-like Mg2+-doped nHA (N-HA) and a more amorphous, rounded Mg2+– and CO32–-doped nHA (R-HA). To investigate the effects of the different compositions and morphologies of these nanoparticles on the bioprinting of human bone marrow stromal cells…