3D Bioplotter Research Papers

Displaying all papers by R. Wiedey (1 results)

Comparative dissolution studies of 3D-printed inserts in a novel biopharmaceutical bladder model

International Journal of Pharmaceutics 2022 Volume 624, Article 121984

Urinary tract disorders come at great discomfort to the patients suffering from them. To treat them, several potent drug substances are available but unfortunately, systemic drug therapy often comes along with undesired adverse effects. Previous work has therefore been conducted aiming at a local drug release in the urinary bladder. However, whether a therapeutically relevant drug concentration may be reached at the target site is not easy to determine when applying common compendial dissolution methods. Therefore, the aim of this study was to develop a biorelevant dissolution model able to take physiological conditions into consideration, i.e. urine flow rates, urination…