3D Bioplotter Research Papers

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Displaying all papers by S. S. Makhathini (1 results)

An Oral 3D Printed PLGA-Tocopherol PEG Succinate Nanocomposite Hydrogel for High-Dose Methotrexate Delivery in Maintenance Chemotherapy

Biomedicines 2022 Volume 10, Issue 7, Article 1470

Authors:P. P. D. Kondiah T. A. Rants\'o S. S. Makhathini S. Mdanda Y. E. Choonara

High-dose methotrexate (HDMTX) is one of the chemotherapeutic agents used to treat a variety of cancers in both adults and children. However, the toxicity associated with HDMTX has resulted in the spread of infections and treatment interruption. Further, poor bioavailability due to efflux pump activities mediated by P-glycoprotein has also been linked to poor therapeutic effects of methotrexate following oral administrations. D-α-Tocopheryl poly-ethylene glycol 1000 succinate (TPGS) is known to improve the bioavailability of poorly soluble drugs by inhibiting P-gp efflux activities, thus enhancing cellular uptake. Therefore, to achieve improved bioavailability for MTX, this study aimed to design and develop…

Keywords:TPGS Alginate Gelatin PLGA Nanoparticles Methotrexate Drug Release Tumor Treatment