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3D Bioplotter Research Papers
Displaying all papers by T. J. Feuerstein (1 results)
Valproate release from polycaprolactone implants prepared by 3D-bioplotting
Die Pharmazie - An International Journal of Pharmaceutical Sciences
2011
Volume 66, Number 7, Pages 511-516
In this study we examined the release kinetics of valproate from polycaprolactone (PCL) implants constructed for local antiepileptic therapy. The PCL implants were produced with a novel 3D-Bioplotting technology. Release kinetics were determined by superfusion of these implants. Valproate was measured in the superfusate fractions with high pressure liquid chromatography (HPLC). The HPLC measurements were linear over a concentration range of 10-500 g/mL for valproate and the limit of quantification was found to be 9 g/mL. The HPLC method used is simple, accurate and sensitive. Within the first day, valproate (10%w/w)-PCL implants released already 77% of the maximum possible liberated…