3D Bioplotter Research Papers

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Displaying all papers by W. G. Loboa (1 results)

The evaluation of a multiphasic 3D-bioplotted scaffold seeded with adipose derived stem cells to repair osteochondral defects in a porcine model

Journal of Biomedical Materials Research, Part B Applied Biomaterials 2021 Volume 109, Issue 12, Pages 2246-2258

Authors:R. C. Nordberg P. Huebner K. G. Schuchard L. F. Mellor R. A. Shirwaiker W. G. Loboa J. T. Spang

There is a need for the development of effective treatments for focal articular cartilage injuries. We previously developed a multiphasic 3D-bioplotted osteochondral scaffold design that can drive site-specific tissue formation when seeded with adipose-derived stem cells (ASC). The objective of this study was to evaluate this scaffold in a large animal model. Osteochondral defects were generated in the trochlear groove of Yucatan minipigs and repaired with scaffolds that either contained or lacked an electrospun tidemark and were either unseeded or seeded with ASC. Implants were monitored via computed tomography (CT) over the course of 4 months of in vivo implantation and…

Keywords:PCL Tricalcium Phosphate Decellualrized ECM Adipose Derived Stem Cells (ADSC) in-vivo (pig) Bone Regeneration Cartilage Regeneration Knee Repair