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3D Bioplotter Research Papers
Displaying all papers by Y. Chi (1 results)
The effect of induced membranes combined with enhanced bone marrow and 3D PLA-HA on repairing long bone defects in vivo
Journal of Tissue Engineering and Regenerative Medicine
2020
Volume 14, Issue 10, Pages 1403-1414
The repair of large bone defects has always been a challenge, especially with respect to regeneration capacity and autogenous bone availability. To address this problem, we fabricated a 3D-printed polylactic acid (PLA) and hydroxyapatite (HA) scaffold (3D-printed PLA-HA, providing scaffold) loaded with enhanced bone marrow (eBM, providing seed cells) combined with induced membrane (IM, providing grow factors) to repair large radial defects in rabbits. in vitro assays, we demonstrated that 3D-printed PLA-HA had excellent biocompatibility, as shown by co-culturing with mesenchymal stem cells (MSCs); eBM-derived MSCs exhibited considerable differentiation potential, as shown in trilineage differentiation assays. To investigate bone formation…