3D Bioplotter Research Papers

Displaying all papers about Coating (Chitosan) (4 results)

A Novel 3D-Printed/Porous Conduit with Tunable Properties to Enhance Nerve Regeneration Over the Limiting Gap Length

Advanced Materials Technologies 2023 Volume 8, Issue 17, Article 2300136

Engineered grafts constitute an alternative to autologous transplant for repairing severe peripheral nerve injuries. However, current clinically available solutions have substantial limitations and are not suited for the repair of long nerve defects. A novel design of nerve conduit is presented here, which consists of a chitosan porous matrix embedding a 3D-printed poly-ε-caprolactone mesh. These materials are selected due to their high biocompatibility, safe degradability, and ability to support the nerve regeneration process. The proposed design allows high control over geometrical features, pores morphology, compression resistance, and bending stiffness, yielding tunable and easy-to-manipulate grafts. The conduits are tested in chronic…

Improved Physiochemical Properties of Chitosan@PCL Nerve Conduits by Natural Molecule Crosslinking

Biomolecules 2023 Volume 13, Issue 12, Article 1712

Nerve conduits may represent a valuable alternative to autograft for the regeneration of long-gap damages. However, no NCs have currently reached market approval for the regeneration of limiting gap lesions, which still represents the very bottleneck of this technology. In recent years, a strong effort has been made to envision an engineered graft to tackle this issue. In our recent work, we presented a novel design of porous/3D-printed chitosan/poly-ε-caprolactone conduits, coupling freeze drying and additive manufacturing technologies to yield conduits with good structural properties. In this work, we studied genipin crosslinking as strategy to improve the physiochemical properties of our…

Toughening 3D-printed Sr–HT–Gahnite caffold through natural and synthetic polymer coating

International Journal of Applied Biomedical Engineering 2020 Volume 13, number 1, Pages 18-22

Bone scaffold for aiding bone regeneration in large bone defects should have following ideal characteristics; biocompatibility, biodegradability, bio-activity, high porous and interconnected-pore architecture, as well as, mechanical characteristics similar to the cortical bone for supporting loads. 3D printed Sr–HT (Sr–Ca2ZnSi2O7)–gahnite scaffold with hexagonal pore structure is an interesting bone scaffold meeting most of these ideal features. To explain, biocompatible, osteoinductive, and osteoconductive properties as well as unique high compressive strength are obtained from Sr–HT–gahnite, glass-ceramic, material. With hexagonal pore structure, the scaffold has compressive strength comparable to cortical bone balancing with high porosity and large pore size. Nonetheless, the scaffold…

Hierarchical Fibrillar Scaffolds Obtained by Non-conventional Layer-By-Layer Electrostatic Self-Assembly

Advanced Healthcare Materials 2013 Volume 2, Issue 3, pages 422–427

A new application of layer-by-layer assembly is presented, able to create nano/micro fibrils or nanocoatings inside 3D scaffolds using non-fibrillar polyelectrolytes for tissue-engineering applications. This approach shows promise for developing advanced scaffolds with controlled nano/micro environments, and nature and architectures similar to the natural extracellular matrix, leading to improved biological performance.