3D Bioplotter Research Papers

Displaying all papers about Phloretic-modified Gelatin Methacrylate (1 results)

Enhanced osteochondral repair with hyaline cartilage formation using an extracellular matrix-inspired natural scaffold

Science Bulletin 2023 Volume 68, Issue 17, Pages 1904-1917

Osteochondral defects pose a great challenge and a satisfactory strategy for their repair has yet to be identified. In particular, poor repair could result in the generation of fibrous cartilage and subchondral bone, causing the degeneration of osteochondral tissue and eventually leading to repair failure. Herein, taking inspiration from the chemical elements inherent in the natural extracellular matrix (ECM), we proposed a novel ECM-mimicking scaffold composed of natural polysaccharides and polypeptides for osteochondral repair. By meticulously modifying natural biopolymers to form reversible guest–host and rigid covalent networks, the scaffold not only exhibited outstanding biocompatibility, cell adaptability, and biodegradability, but also…