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Displaying all papers about Ru(BPY)3 (1 results)

GelMA Hydrogel Reinforced with 3D Printed PEGT/PBT Scaffolds for Supporting Epigenetically-Activated Human Bone Marrow Stromal Cells for Bone Repair

Journal of Functional Biomaterials 2022 Volume 13, Issue 2, Article 14

Authors:K. Man C. Alcala N. V. Mekhileri K. S. Lim L-H. Jiang T. B. F. Woodfield X. B. Yang

Epigenetic approaches using the histone deacetylase 2 and 3 inhibitor-MI192 have been reported to accelerate stem cells to form mineralised tissues. Gelatine methacryloyl (GelMA) hydrogels provide a favourable microenvironment to facilitate cell delivery and support tissue formation. However, their application for bone repair is limited due to their low mechanical strength. This study aimed to investigate a GelMA hydrogel reinforced with a 3D printed scaffold to support MI192-induced human bone marrow stromal cells (hBMSCs) for bone formation. Cell culture: The GelMA (5 wt%) hydrogel supported the proliferation of MI192-pre-treated hBMSCs. MI192-pre-treated hBMSCs within the GelMA in osteogenic culture significantly increased…

Keywords:PEGT/PBT Gelatin Methacrylate Sodium Persulfate Ru(BPY)3 Mesenchymal stem cells (MSCs) Cell Printing Bone Regeneration