3D Bioplotter Research Papers

3D printing enables precise control over tablet design and drug release, but challenges remain in optimising ink formulation, ensuring printability, and predicting final tablet properties. This study addresses the need for data-driven strategies in fabricating chewable tablets and tests the hypothesis that integrating rheology with machine learning (ML) enables predictive control over print quality and dosage form performance. We developed drug nanosuspension inks with varying water content (85–20 wt.%) and identified 40% as optimal, balancing shear-thinning behaviour, yield stress, and shear recovery for consistent extrusion. Analytical models predicted strut diameter (D) based on printing parameters—pressure (P), speed (v), and nozzle…

Biology uses various cross-linking mechanisms to tailor material properties, and this is inspiring technological efforts to couple independent cross-linking mechanisms to create hydrogels with complex mechanical properties. Here, it is reported that a hydrogel formed from a single polysaccharide can be triggered to reversibly switch cross-linking mechanisms and switch between elastic and viscoelastic properties. Specifically, the pH-responsive self-assembling aminopolysaccharide chitosan is used. Under acidic conditions, chitosan is polycationic and can be electrostatically cross-linked by sodium dodecyl sulfate (SDS) micelles to confer viscoelastic and self-healing properties. Under basic conditions, chitosan becomes neutral, the electrostatic SDS–chitosan interactions are no longer operative, and…