Elastic polyurethane bearing pendant TGF-β1 affinity peptide for potential tissue engineering applications
* An elastic degradable polyurethane (PU) bearing pendent HSNGLPL peptide for TGF-β1 affinity binding mimics the extracellular matrix function to retain and release growth factors.
* The pendant peptide sequence presented a high affinity for TGF-β1 retaining, even when the surface was pre-coated with other proteins.
* The synthesized PU shows good extrusion processing ability and can be printed into 3D scaffolds with designed porous structures.
* The released TGF-β1 from surface conjugating was tested by differentiation guiding experiments of ATDC5 cells in vitro and the regeneration of the surrounding tissue after implanting in vivo.