[Performance of 3D-printed polylactic acid-nano-hydroxyapatite/chitosan/doxycycline antibacterial scaffold]

BACKGROUND: Polylactic acid has good biocompatibility and biodegradability, and has become a new orthopedic fixation material. However, the lack of cell recognition signal of this material is not conducive to cell adhesion and osteogenic differentiation, which limits its application in biomaterials.

OBJECTIVE: 3D-printed polylactic acid-nano-hydroxyapatite (nHA)/chitosan (CS) scaffold to evaluate its drug sustained-release and biological properties