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ZEB2, a master regulator of the epithelial-mesenchymal transition, mediates trophoblast differentiation

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MHR: Basic science of reproductive medicine 2018 Volume 25, Issue 2, Pages 61–75
S. DaSilva-Arnold C-Y. Kuo V. Davra Y. Remache P. C. W. Kim J. P. Fisher S. Zamudio A. Al-Khan R. B. Birge N. P. Illsley

STUDY QUESTION
Does the upregulation of the zinc finger E-box binding homeobox 2 (ZEB2) transcription factor in human trophoblast cells lead to alterations in gene expression consistent with an epithelial-mesenchymal transition (EMT) and a consequent increase in invasiveness?

SUMMARY ANSWER
Overexpression of ZEB2 results in an epithelial-mesenchymal shift in gene expression accompanied by a substantial increase in invasive capacity of human trophoblast cells.

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