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3D Bioplotter Research Papers
Displaying all papers by D. Oakes (1 results)
Regional gene therapy for bone healing using a 3D printed scaffold in a rat femoral defect model
Journal of Biomedical Materials Research Part A
2021
Volume 109, Issue 11, Pages 2346-2356
At the present time there are no consistently satisfactory treatment options for some challenging bone loss scenarios. We have previously reported on the properties of a novel 3D-printed hydroxyapatite-composite material in a pilot study, which demonstrated osteoconductive properties but was not tested in a rigorous, clinically relevant model. We therefore utilized a rat critical-sized femoral defect model with a scaffold designed to match the dimensions of the bone defect. The scaffolds were implanted in the bone defect after being loaded with cultured rat bone marrow cells (rBMC) transduced with a lentiviral vector carrying the cDNA for BMP-2. This experimental group…