3D Bioplotter Research Papers

A myocardial infarction can cause irreversible damage to the heart muscle. A promising approach for the treatment of myocardial infarction and prevention of severe complications is the application of cardiac patches or epicardial restraint devices. The challenge for the fabrication of cardiac patches is the replication of the fibrillar structure of the myocardium, in particular its anisotropy and local elasticity. In this study, we developed a chitosan-gelatin-guar gum-based biomaterial ink that was fabricated using 3D printing to create patterned anisotropic membranes. The experimental results were then used to develop a numerical model able to predict the elastic properties of additional…

Myocardial infarction can cause irreversible damage to the heart muscle, which can lead to heart failure. The difficulty of the treatment mainly arises from the anisotropic behavior of the myocardium fibrous structure. Patches or cardiac restraint devices appear to be a promising approach to post-infarction treatment. In this study, we propose a new model-assisted method to design patterned membranes. The proposed approach combines computer experiments and statistical models to optimize the design parameters and to meet the requirement for the post-infarction treatment. Finite element model, global sensitivity analysis, random forest model and response surface model are the key components of…

3D bioprinting stands out as one of the most promising innovations in the field of high technologies for personalized biomedicine, enabling the fabrication of biomaterial-based scaffolds designed to repair, restore, or regenerate tissues and organs in the body. Among the various materials used as inks, hydrogels play a critical role due to their unique characteristics, including excellent biocompatibility, adjustable mechanical properties, and high solvent retention. This versatility makes them ideal for various applications such as biomedical devices, drug delivery, or flexible electronics. Although chitosan is a promising material for such applications, when used alone, it does not possess the necessary…