3D Bioplotter Research Papers

3D-printed bioceramics derived from silicone resin are of great interest in bone tissue engineering owing to their simple processes and low cost. Herein, PCN-224, as a subclass of metal−organic frameworks (MOFs), is successfully fabricated and deposited on the surface of 3D-printed porous β-Ca2SiO4 (C2S) scaffolds. The composite scaffolds possess uniform interconnected macropores (≈400 μm), with increased porosity and slower degradation. The results indicate that deposition of PCN-224 significantly promotes cell proliferation and the expression of osteogenesis-related genes. Moreover, the composite scaffolds significantly improve calvarial defect healing in rats, compared with C2S scaffolds. Therefore, the PCN-224-modified 3D-printed porous C2S composite scaffolds are…

Poly (lactic-co-glycolic acid) (PLGA) is a star biodegradable polymer widely studied and applied in the biomedical field. Improving the acidic microenvironment caused by its degradation products and regulating its degradation behavior are still urgent scientific and technological problems to be solved. In this study, to regulate the degradation behaviors of PLGA and improve its bioactivity, hydroxyapatite (HA) and magnesium oxide (MgO) were incorporated into PLGA substrate in different proportions and a series of 3D-printing PLGA/HA/MgO (PHM) composite porous scaffolds were prepared. Then the physicochemical properties, degradation behaviors, in vitro and in vivo biological performance of fabricated scaffolds were systematically studied.…