™
3D Bioplotter Research Papers
Displaying all papers by J. R. Lieberman (1 results)
3D printed hyperelastic “bone” scaffolds and regional gene therapy: A novel approach to bone healing
Journal of Biomedical Materials Research
2018
Volume 106, Issue 4, Pages 1104-1110
The purpose of this study was to evaluate the viability of human adipose-derived stem cells (ADSCs) transduced with a lentiviral (LV) vector to overexpress bone morphogenetic protein-2 (BMP-2) loaded onto a novel 3D printed scaffold. Human ADSCs were transduced with a LV vector carrying the cDNA for BMP-2. The transduced cells were loaded onto a 3D printed Hyperelastic “Bone” (HB) scaffold. In vitro BMP-2 production was assessed using enzyme-linked immunosorbent assay analysis. The ability of ADSCs loaded on the HB scaffold to induce in vivo bone formation in a hind limb muscle pouch model was assessed in the following groups:…