3D Bioplotter Research Papers

Purpose This study investigates the effect of 3D-bioplotted polycaprolactone (PCL) scaffold geometry on the biological and mechanical characteristics of human adipose-derived stem cell (hASC) seeded constructs. Design/methodology/approach Four 3D-bioplotted scaffold disc designs (Ø14.5 x 2 mm) with two levels of strand-pore feature sizes and two strand laydown patterns (0°/90° or 0°/120°/240°) were evaluated for hASC viability, proliferation, and construct compressive stiffness after 14 days of in vitro cell culture. Findings Scaffolds with the highest porosity (smaller strand-pore size in 0°/120°/240°) yielded the highest hASC proliferation and viability. Further testing of this design in a 6 mm thick configuration showed that…