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3D Bioplotter Research Papers
Establishing a 3D bioprinter in a biomedical research laboratory for the high resolution rapid prototyping of an auxetic cardiac patch
A recent development in biomedical research might hold the key to a successful revival of damaged cardiac tissue after Myocardial Infarction (MI): Cardiac patches are functioningcardiac tissue constructs, grown in-vitro, to replace and support the patient’s diseased tissue.The aim is to bridge mechanical and electrical stimulations and provide a stable substrate forcell-attachment and cell-growth. Scaffolds from biocompatible and biodegradable polymerslike polycaprolactone (PCL) provide good mechanical stability, but rarely provide the desired bioactive properties for tissue engineering. The solution for a successful patch might be the combination of hydrogel encapsulated cells with a stable polymer scaffold, to obtain a composite biomaterial.Certain…
Silk fibroin, gelatin, and human placenta extracellular matrix-based composite hydrogels for 3D bioprinting and soft tissue engineering
Background There is a great clinical need and it remains a challenge to develop artificial soft tissue constructs that can mimic the biomechanical properties and bioactivity of natural tissue. This is partly due to the lack of suitable biomaterials. Hydrogels made from human placenta offer high bioactivity and represent a potential solution to create animal-free 3D bioprinting systems that are both sustainable and acceptable, as placenta is widely considered medical waste. A combination with silk and gelatin polymers can bridge the biomechanical limitations of human placenta chorion extracellular matrix hydrogels (hpcECM) while maintaining their excellent bioactivity. Method In this…