3D Bioplotter Research Papers

BACKGROUND: Uneven secretion of matrix and insufficient mechanical strength are important factors affecting the formation effect of tissue engineering constructs in vivo. Mechanical stimulation is an effective means to promote the secretion of extracellular matrix. OBJECTIVE: To explore the biological performance of 3D bioprinted composite scaffolds under mechanical stimulation. METHODS: The chondrocyte-gelatin methacryloyl composite scaffold was prepared and printed by 3D bioprinting technology. Cell survival was observed by live/dead cell staining. The composite scaffolds were placed in a mechanical pressurized bioreactor for pressurized culture. The composite scaffolds cultured in a 6-well plate without pressurization were used as the control. Live/dead…