3D Bioplotter Research Papers

Auxetic scaffolds fabricated via additive manufacturing can enable cyclic mechanical stimulation to promote the biomechanical functionalization of engineered tissues. Typical designs of additively manufactured scaffolds used in tissue engineering literature (e.g., 0/90˚ strand laydown) are not amenable to cyclic loading due to their rigidity, which is in part due to the high stiffness of biopolymers such as polycaprolactone (PCL). Auxetic scaffolds can help overcome this due to their design-induced elasticity while recapitulating negative Poisson’s ratios seen in various natural tissues. In this study, we investigated the effects of auxetic design patterns and unit cell sizes on the mechanical properties of…

Biofabrication, which integrates biological sciences with advanced manufacturing, is vital for innovations in tissue engineering and regenerative medicine. One primary consideration in this domain is ensuring consistent, scalable, and adaptable processes that are amenable to clinical translation. Toward this, this paper introduces a new framework for digital twin integration in biofabrication. Digital twins, which are real-time virtual replicas of physical systems, can facilitate comprehensive monitoring, accurate prediction, and effective optimization to enable robust biofabrication processes and systems. The proposed framework incorporates major building blocks for implementing digital twins for biofabrication, including comprehensive data acquisition and analysis using sophisticated sensors to…