3D Bioplotter Research Papers

Low-intensity pulsed ultrasound (LIPUS) assisted bone repair is confirmed effective in clinic. Here, a 3D-printed composite poly(DL-lactic acid)/mesoporous bioactive glass scaffold was constructed for particular use in LIPUS-assisted bone tissue engineering. The scaffolds contain dimethyloxallyl glycine (DMOG) loaded microbubbles in pores, which can be released after implanting via LIPUS stimulation. Local DMOG concentrations are modulated through ultrasound power and processing time. The rat bone marrow-derived mesenchymal stem cells (rBMSCs) on these scaffolds with ultrasound treatment show improved proliferation and early osteogenic differentiation.

Pb0.99(Zr0.95Ti0.05)0.98Nb0.02O3 ferroelectric ceramics with porous structure of periodic distribution were fabricated successfully via Direct Ink Writing, a type of 3D printing technique. The effect of periodically distributed porous microstructure on the dielectric, ferroelectric, as well as hydrostatic-pressure-induced depolarization properties of PZT95/5 ferroelectric ceramics, was investigated. The printed porous ceramics exhibit relatively good viscoelasticity to retain the periodic structure during 3D printing and drying. In contrast with dense PZT95/5 ferroelectric ceramics prepared by conventional solid-state sintering, low bulk density of the periodically distributed porous PZT95/5 ceramics leads to a decreased remanent polarization of 22.9 µC/cm2 under 2 kV/mm. As the hydrostatic pressure…

Osteochondral defects affect both of cartilage and subchondral areas, thus it poses a significant challenge to simultaneously regenerate two parts in orthopedics. Tissue engineering strategy is currently regarded as the most promising way to repair osteochondral defects. This study focuses on developing a multilayered scaffold with enhanced interface bonding through 3D printing. One-shot printing process enables control over material composition, pore structure, and size in each region of the scaffold, while realizes seamlessly integrated construct as well. The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate…