3D Bioplotter Research Papers

The membrane based on receptor functionalization provides a new paradigm for the development of mechanical biosensors. However, improvement of sensitivity and test accuracy is still a challenge for mechanical biosensors in practical application. Herein, a surface stress mechanical biosensor (MBioS) based on double-side-gold nanoparticale (AuNP)-coated grid-type polydimethylsiloxane (PDMS) membrane (D-G-MBioS) and 3D printing for human serum albumin (HSA) detection is developed. The surface stress is amplified by the grid coupling sandwich immune structure to improve the sensitivity of the MbioS, successfully reducing limite of detection (LOD) by two orders of magnitude. By self-assembly of AuNPs, the double-side-coated PDMS membrane is…