3D Bioplotter Research Papers

Objectives There are complications in applying regenerative strategies at the interface of hard and soft tissues due to the limited designs of constructs that can accommodate different cell types in different sites. The problem originates from the challenges in the adhesion of dissimilar materials, such as polymers and hydrogels, that can be suitable for regenerating different tissues such as bone and soft tissues. This paper presents a design of a new hybrid construct in which a polymer (polycaprolactone (PCL)) membrane firmly adheres to a layer of hydrogen (gelatin). Methods PCL membranes with defined size and porosity were fabricated using 3D…

Objectives: The current study aimed to perform an in vivo examination using a critical-size periodontal canine model to investigate the capability of a 3D-printed soft membrane for guided tissue regeneration (GTR). This membrane is made of a specific composition of gelatin, elastin, and sodium hyaluronate that was fine-tuned and fully characterized in vitro in our previous study. The value of this composition is its potential to be employed as a suitable replacement for collagen, which is the main component of conventional GTR membranes, to overcome the cost issue with collagen. Methods: Critical-size dehiscence defects were surgically created on the buccal…

Fluoropolymers are amongst the most common polymers used for the fabrication of filtration membranes. Despite this, commercial production of these membranes remains dominated by simple casting and solvent phase separation. Herein, we show a rapid, simple approach to produce fluoropolymer membranes, with a porous patterned surface, via immersion precipitation printing (ipP). The patterns can act as a permeate spacer, which are traditionally added to a membrane separately to induce turbulent flow and subsequently decreasing membrane fouling. The direct phase inversion of the permeate spacer during membrane production induces a porous morphology. Further, intimate mechanical connection between the membrane surface and…

Here, a hybrid process for the fabrication of dehydrofluorinated PVDF (dPVDF) microfiltration (MF) membranes is presented. dPVDF was fabricated through the bulk modification of PVDF using ethylenediamine. To produce inks for direct ink writing (DIW), the dPVDF was dissolved in N,N-dimethyacetamide along with a pore-forming agent, poly(vinyl pyrrolidone) (PVP) (5–30 wt%, relative to dPVDF concentration). Membranes were produced by direct ink writing of the inks into continuous films – followed by non-solvent induced phase separation (NIPS). Attenuated total reflectance – Fourier transform infrared (ATR-FTIR) and Raman spectroscopies confirmed alkene moieties within the dPVDF polymer, resulting from the dehydrofluorination process. The…