3D Bioplotter Research Papers

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Displaying all papers about Rifampicin (1 results)

3D-printed dual drug delivery nanoparticleloaded hydrogels to combat antibiotic-resistant bacteria

International Journal of Bioprinting 2023 Volume 9, Issue 3, Article 683

Authors:D. Martínez-Pérez C. Guarch-Pérez M. A. K. Purbayanto E. Choińska M. Riool S. A. J. Zaat W. Swieszkowski

Implant-associated infections are not easy to diagnose and very difficult to treat, due to the ability of major pathogens, such as Staphylococcus aureus, to develop biofilms and escape the immune response and antibiotic treatment. We, therefore, aimed to develop a 3D-printed dual rifampicin (Rif)- and vancomycin (Van)-loaded polylacticco-glycolic acid (PLGA) nanoparticles (NPs) delivery system based on hydrogels made of gelatin methacrylate (GelMA). The release of Rif and Van from NPs manufactured from different PLGA molecular weights was studied in phosphate-buffered saline for 21 days. Low molecular weight PLGA NPs exhibited the fastest release of Rif and Van within the first…

Keywords:Gelatin Methacrylate Irgacure 2959 Rifampicin Vancomycin Antibiotics PLGA Nanoparticles in-vitro Drug Release Bacterial Adhesion Soft Tissue Regeneration