3D Bioplotter Research Papers

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Displaying all papers about ssDNA (1 results)

A novel vehicle-like drug delivery 3D printing scaffold and its applications for a rat femoral bone repairing in vitro and in vivo

International Journal of Biological Sciences 2020 Volume 16, Issue 11, Pages 1821-1832

Authors:H. Wang Z. Deng J. Chen X. Qi L. Pang B. Lin Y. T. Y. Adib N. Miao D. Wang Y. Zhang J. Li X. Zeng

The high surface area ratio and special structure of mesoporous bioactive glass (MBG) endow it with excellent physical adsorption of various drugs without destroying the chemical activity. Silicate 1393 bioactive glass (1393) is famous for its fantastic biodegradability and osteogenesis. Herein, we have built a novel vehicle-like drug delivery 3D printing scaffold with multiplexed drug delivery capacity by coating MBG on the surface of 1393 (1393@MBG). Furthermore, we have applied DEX and BMP-2 on the 1393@MBG scaffold to endow it with antibacterial and osteogenic properties. Results indicated that this 1393@MBG scaffold could effectively load and controlled release BMP-2, DNA and…

Keywords:Mesoporous Bioactive Glass Ethylcellulose ssDNA Dexamethasone Growth Factor (BMP-2) Drug Release Bacterial Adhesion Mesenchymal stem cells (MSCs) in-vivo (rat) Bone Regeneration