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3D Bioplotter Research Papers
Zr-based metal-organic framework nanocrystals improve the osteoinductivity and osteogenicity of alginate/methyl cellulose bioink
Addressing critical-sized bone defects poses significant challenges due to the limitations of natural bone regeneration and conventional treatments like tissue transplantation. Bone tissue engineering and 3D bioprinting offer promising solutions by creating customized, biomimetic scaffolds. This study explores the innovative use of UiO-66 metal-organic framework (MOF) nanocrystals to enhance the osteoinductive and osteogenic properties of 3D bioprinted scaffolds. UiO-66 nanocrystals were synthesized and characterized, demonstrating uniform morphology and highly crystalline structure. These nanocrystals were then incorporated into alginate/methyl cellulose (AL/MC) hydrogel at various concentrations and print parameters were optimized based on physicochemical properties. AL/MC/UiO-66 optimized under specific conditions was then…