3D Bioplotter Research Papers

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Displaying all papers by H. Ao (1 results)

Anti-infective efficacy, cytocompatibility and biocompatibility of a 3D-printed osteoconductive composite scaffold functionalized with quaternized chitosan

Acta Biomaterialia 2016 Volume 46, Pages 112-128

Authors:Y. Yang S. Yang Y. Wang Z. Yu H. Ao H. Zhang L. Qin O. Guillaume D. Eglin R. G. Richards T. Tang

Contaminated or infected bone defects remain serious challenges in clinical trauma and orthopaedics, and a bone substitute with both osteoconductivity and antibacterial properties represents an improvement for treatment strategy. In this study, quaternized chitosan (hydroxypropyltrimethyl ammonium chloride chitosan, HACC) was grafted to 3D-printed scaffolds composed of polylactide-co-glycolide (PLGA) and hydroxyapatite (HA), in order to design bone engineering scaffolds endowed with antibacterial and osteoconductive properties. We found that both the PLGA/HA/HACC and PLGA/HACC composite scaffolds decreased bacterial adhesion and biofilm formation under in vitro and in vivo conditions. Additionally, ATP leakage assay indicated that immobilizing HACC on the scaffolds could effectively…

Keywords:PLGA Hydroxyapatite Coating (Hydroxypropyltrimethyl ammonium chloride chitosan) Bacterial Adhesion Antimicrobial Mesenchymal stem cells (MSCs) in-vivo (rat) Bone Regeneration