3D Bioplotter Research Papers

Melanoma is one of the most aggressive types of skin cancer, and the need for advanced platforms to study this disease and to develop new treatments is rising. 3D bioprinted tumor models are emerging as advanced tools to tackle these needs, with the design of adequate bioinks being a fundamental step to address this challenging process. Thus, this work explores the synergy between two biobased nanofibers, nanofibrillated cellulose (NFC) and lysozyme amyloid nanofibrils (LNFs), to create pectin nanocomposite hydrogel bioinks for the 3D bioprinting of A375 melanoma cell-laden living constructs. The incorporation of LNFs (5, 10 or 15 wt%) on a…

We report herein the fabrication of a pectin-based scaffold (6 wt% pectin, 3 wt% alginate) with high resolution (small-diameter rods), small pores, and interconnected porosity using a low temperature 3D printing process known as freeze-printing. The ability to successfully print natural polymers has been a long-standing challenge in the field of additive manufacturing of polymeric tissue scaffolds. This is due to the slow evaporation rate of the aqueous solvent, which leads to unstable structures. This problem has been addressed by utilizing the fast solidification rate of the freeze-printing process. Scaffolds with a hgresolution (rod-diameter of 83 ± 14 µm), small…

Sutures are one of the most widely used medical devices with employment in over 12 million procedures per year globally.1 Yet, the ideal suture material does not exist. Over the years scientists and surgeons alike have set out to find a suture material that is biocompatible, easy to handle, does not cause unnecessary tissue damage and creates an optimal environment for wound healing.2 This has led to the discovery of numerous suture materials ranging from silk and catgut in the early 1800s to synthetic polymers such as polylactic acid and polyglycolide that are currently in use.3 Sutures on the market…