3D Bioplotter Research Papers

Displaying all papers by H. Wang (6 results)

Regional specific tunable meniscus decellularized extracellular matrix (MdECM) reinforced bioink promotes anistropic meniscus regeneration

Chemical Engineering Journal 2023 Volume 473, Article 145209

The healing of meniscus injuries poses a significant challenge, as prolonged failure to heal can lead to osteoarthritis, which presents a therapeutic dilemma in the field of sports medicine. Decellularized extracellular matrix (MdECM) derived from natural meniscus, and the incorporated growth factors have been used for potential fibrochondrocyte induction and meniscus regeneration. However, homogeneous MdECM is difficult to achieve region-specific biomimetic microenvironment for tissue regeneration. In this study, we successfully prepared a region-specific MdECM, which were then mixed with an ultraviolet responsible Gelatin Methacryloyl (GelMA)/hyaluronic acid Methacryloy (HAMA) hydrogel incorporated with bioactive factors, faciliatated a functional region-specific bioink. The 3D…

3D Printing and Performance Study of Porous Artificial Bone Based on HA-ZrO2-PVA Composites

Materials 2023 Volume 16, Issue 3, Article 1107

An ideal artificial bone implant should have similar mechanical properties and biocompatibility to natural bone, as well as an internal structure that facilitates stomatal penetration. In this work, 3D printing was used to fabricate and investigate artificial bone composites based on HA-ZrO2-PVA. The composites were proportionally configured using zirconia (ZrO2), hydroxyapatite (HA) and polyvinyl alcohol (PVA), where the ZrO2 played a toughening role and PVA solution served as a binder. In order to obtain the optimal 3D printing process parameters for the composites, a theoretical model of the extrusion process of the composites was first established, followed by the optimization…

MicroRNA-activated hydrogel scaffold generated by 3D printing accelerates bone regeneration

Bioactive Materials 2022 Volume 10, Pages 1-14

Bone defects remain a major threat to human health and bone tissue regeneration has become a prominent clinical demand worldwide. The combination of microRNA (miRNA) therapy with 3D printed scaffolds has always posed a challenge. It can mimic physiological bone healing processes, in which a biodegradable scaffold is gradually replaced by neo-tissue, and the sustained release of miRNA plays a vital role in creating an optimal osteogenic microenvironment, thus achieving promising bone repair outcomes. However, the balance between two key factors – scaffold degradation behavior and miRNA release profile – on osteogenesis and bone formation is still poorly understood. Herein,…

Integrative treatment of anti-tumor/bone repair by combination of MoS2 nanosheets with 3D printed bioactive borosilicate glass scaffolds

Chemical Engineering Journal 2020 Volume 396, Article 125081

Malignant bone tumors have caused great obstacles and serious illnesses for tumor recurrence and difficulty in reconstructing and repairing large defects after tumorectomy. Additionally, long-term efficacy, satisfactory biocompatibility and excellent properties for anti-tumor agents are necessary in the biomedical field. To solve these problems, a novel idea has been proposed on building an integrative anti-tumor/bone repairing scaffold by covering photothermal therapy (PTT) composite MoS2-PLGA film on the surface of borosilicate bioactive glass (BG). In our study, the MoS2-integrated composite BG (BGM) scaffolds can rapidly and effectively elevate temperature, and they exhibited excellent photothermal stability, under 808 nm laser irradiation. Notably,…

A novel vehicle-like drug delivery 3D printing scaffold and its applications for a rat femoral bone repairing in vitro and in vivo

International Journal of Biological Sciences 2020 Volume 16, Issue 11, Pages 1821-1832

The high surface area ratio and special structure of mesoporous bioactive glass (MBG) endow it with excellent physical adsorption of various drugs without destroying the chemical activity. Silicate 1393 bioactive glass (1393) is famous for its fantastic biodegradability and osteogenesis. Herein, we have built a novel vehicle-like drug delivery 3D printing scaffold with multiplexed drug delivery capacity by coating MBG on the surface of 1393 (1393@MBG). Furthermore, we have applied DEX and BMP-2 on the 1393@MBG scaffold to endow it with antibacterial and osteogenic properties. Results indicated that this 1393@MBG scaffold could effectively load and controlled release BMP-2, DNA and…

Effects of 3-dimensional Bioprinting Alginate/ Gelatin Hydrogel Scaffold Extract on Proliferation and Differentiation of Human Dental Pulp Stem Cells

Journal of Endodontics 2019 Volume 45, Issue 6, Pages 706-715

Abrasive flow machining (AFM) is a nontraditional surface finishing method that finishes complex surface by pushing the abrasive media flow through the workpiece surface. The entrance effect that the material removal increases at the entrance of changing the cross-sectional flow channel is a difficult problem for AFM. In this paper, the effects of media rheological properties on the entrance effect are discussed. To explore the effects of the media’s viscoelasticity on the entrance effect, two sets of media with different viscoelasticity properties are adopted to study their rheological and machining performances in the designed flow channel with a contraction area.…