3D Bioplotter Research Papers

Systemic chemotherapy after surgery is necessary to control tumor recurrence, but the severe side effects caused by chemotherapeutic drugs pose a great threat to patients’ health. In this study, we originally develop a porous scaffold used for chemotherapy drug capture by using 3D printing technology. The scaffold is mainly composed of poly (ε-caprolactone) (PCL) and polyetherimide (PEI) with a mass ratio of 5/1. Subsequently, the printed scaffold is modified with DNA through the strong electrostatic integration between DNA and PEI to endow the scaffold with the specific absorption to doxorubicin (DOX, a widely used chemotherapy drug). The results show that…

We report herein the fabrication of a pectin-based scaffold (6 wt% pectin, 3 wt% alginate) with high resolution (small-diameter rods), small pores, and interconnected porosity using a low temperature 3D printing process known as freeze-printing. The ability to successfully print natural polymers has been a long-standing challenge in the field of additive manufacturing of polymeric tissue scaffolds. This is due to the slow evaporation rate of the aqueous solvent, which leads to unstable structures. This problem has been addressed by utilizing the fast solidification rate of the freeze-printing process. Scaffolds with a hgresolution (rod-diameter of 83 ± 14 µm), small…

Organ-on-a-chip (OOC) is now becoming a potential alternative to the classical preclinical animal models, which reconstitutes in vitro the basic function of specific human tissues/organs and dynamically simulates physiological or pathological activities in tissue and organ level. Despite of the much progress achieved so far, there is still an urgent need to explore new biomaterials to construct a reliable and efficient tissue–tissue interface and a general fabrication strategy to expand from single-organ OOC to multi-organ OOC in an easy manner. In this paper, we propose a novel strategy to prepare double-compartment organ-on-a-chip (DC-OOC) using electrospun poly(l-lactic acid)/collagen I (PLLA/Col I)…