3D Bioplotter Research Papers

Background: Given the limitations of traditional therapies, the treatment of infected bone defects (IBD) remains a great challenge. It is urgent to find a novel method that can simultaneously eradicate infection and promote new bone formation. With the increasing application of personalized scaffolds in orthopedics, novel biomaterials with both antibacterial and osteoinductive properties have provided a viable option for IBD treatment. Through the three-dimensional (3D) printing technology, we fabricated a poly(lactic-co-glycolic acid)(PLGA)/nano-hydroxyapatite (n-HA) composite scaffold grafted with the antibiotic vancomycin and loaded with the osteoinductive agent recombinant human bone morphogenic protein-2 (rhBMP-2) via polydopamine (DOPA) chemistry, whose therapeutic effects on…

The 3D printing process can produce bioengineered scaffolds with a 100% interconnected porous structure layer-by-layer with the help of computer-aided design. In this study we utilized a 3D bio plotter system to fabricate 3D interconnected porous scaffolds for bone tissue engineering. Poly (L-lactide-co-caprolactone (PLCL)) was selected to fabricate the scaffold due to its biocompatibility and printability. Two scaffolds were produced for comparative study with a layer rotation of 45° and 90° and a distance of either 1000 µm or 1200 µm between the printed fibers. Micro computed tomography (µ-CT) was utilized to study the interconnected porous structure of the scaffolds.…