3D Bioplotter Research Papers

The 3D printing process can produce bioengineered scaffolds with a 100% interconnected porous structure layer-by-layer with the help of computer-aided design. In this study we utilized a 3D bio plotter system to fabricate 3D interconnected porous scaffolds for bone tissue engineering. Poly (L-lactide-co-caprolactone (PLCL)) was selected to fabricate the scaffold due to its biocompatibility and printability. Two scaffolds were produced for comparative study with a layer rotation of 45° and 90° and a distance of either 1000 µm or 1200 µm between the printed fibers. Micro computed tomography (µ-CT) was utilized to study the interconnected porous structure of the scaffolds.…

In this study, two-component, morphologically composite scaffolds consisting of a 3D-printed component and an electrospun fiber component were fabricated and treated with a nitrogen-argon (N2-Ar) plasma to enhance their surface properties. The 3D-printed component provided mechanical strength, while the electrospun fibrous component acted as a mimic to the extracellular matrix to improve cell-substrate interactions. Two biodegradable polyesters, poly(L-lactide-co–ε-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA), were used to create the scaffolds. The resulting 3D/E/N2-Ar scaffolds were characterized in terms of surface properties (morphology, chemical compositions, wettability, roughness, crystallinity), degradation, mechanical properties, and cell cytotoxicity, cell attachment and proliferation, LDH release and cell apoptosis.…

Large size bone defects affect human health and remain a worldwide health problem that needs to be solved immediately. 3D printing technology has attracted substantial attention for preparing penetrable multifunctional scaffolds to promote bone reconditioning and regeneration. Inspired by the spongy structure of natural bone, novel porous degradable scaffolds have been printed using polymerization of lactide and caprolactone (PLCL) and bioactive glass 45S5 (BG), and polydopamine (PDA) was used to decorate the PLCL/BG scaffolds. The physicochemical properties of the PLCL/BG and PLCL/BG/PDA scaffolds were measured, and their osteogenic and angiogenic effects were characterized through a series of experiments both in…